Millet JK, Jaimes JA and Whittaker GR: Molecular diversity of coronavirus host cell entry receptors. Li F: Receptor recognition mechanisms of coronaviruses: a decade of structural studies. Maramorosch K, Murphy FA and Shatkin AJ (eds). Lai MMC and Cavanagh D: The Molecular Biology of Coronaviruses. In: Coronaviruses: Methods and Protocols. Wang Y, Grunewald M and Perlman S: Coronaviruses: An Updated Overview of Their Replication and Pathogenesis. Korsman SNJ, van Zyl GU, Nutt L, Andersson MI and Preiser W: Human coronaviruses. Woo P, Lau S, Lam C, Lau C, Tsang A, Lau J, Bai R, Teng J, Tsang C-C, et al.: Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus. Mavrodiev EV, Tursky ML, Mavrodiev NE, Ebach MC and Williams DM: On Classification and Taxonomy of Coronaviruses (Riboviria, Nidovirales, Coronaviridae) with the special focus on severe acute respiratory syndrome-related coronavirus 2 (SARS-Cov-2). Data mining approaches of this scale have the potential to elucidate the complex interaction between COVID-19 pathogenesis and host genetic variation the resulting knowledge can facilitate the management of high-risk groups and aid the efforts toward precision medicine. Population data from the 1000 Genomes Project were subsequently integrated into the pipeline. We present a semantic analysis of SARS-CoV-2-related publications, which yielded a repertoire of SNPs, genes, and disease ontologies. This genomic grammar, tightly related to the dark part of our genome, can be explored through the use of modern methods such as natural language processing. Toward this goal, scientific attention is shifting toward variants and SNPs that affect factors of the disease such as susceptibility and severity. Vaccination efforts are being made to hinder the viral spread, and therapeutics are currently under development. The virus gains entrance to human cells through binding to ACE2 via its surface spike protein and causes a complex disease of the respiratory system, termed COVID-19. By late 2021, SARS-CoV-2 has infected more than 180 million people and has killed more than 3 million. Yet some highly engaged social media posts misleadingly claim that the government has admitted there will be more myocarditis hospitalizations than those for coronavirus.SARS-CoV-2 is a coronavirus responsible for one of the most serious, modern worldwide pandemics, with lasting and multifaceted effects. While experts with the FDA theorized a scenario where, if Covid-19 transmission were low, the number of “ myocarditis-related hospitalizations in boys in this age group would be slightly more than Covid-related hospitalizations,” they still confirm the benefits of vaccination outweighing concerns about side effects. Still, recent studies have confirmed these cases to be extremely rare and mostly benign.Īdditionally, an FDA document on recommending the vaccine for children ages 5-11 was taken out of context by these actors to justify their anti-vaccination stance. One of the many theories researchers are considering, according to the report, is the possibility that the spike protein, which is produced by the body after receiving the vaccine, might share similarities with ones found in the heart muscle, tricking the immune system into attacking the heart muscle. Yet these disinformation actors baselessly claimed the vaccine itself sends spike protein into a recipient’s “cell nuclei” and “suppresses DNA repair engine.” This narrative is misleading because “mRNA never enters the nucleus of the cell where our DNA (genetic material) is located, so it cannot change or influence our genes,” reads a CDC fact sheet.Ī recent Wall Street Journal report on scientists looking into how the mRNA-based vaccines could trigger myocarditis, pericarditis or other heart inflammation symptoms in a small number of recipients also drew attention from vaccine and pandemic skeptics. Natural News, InfoWars and other well-known disinformation actors intentionally misinterpreted a recently published paper on a potential mechanism of how full-length spike protein found on the coronavirus could diminish a person’s DNA repair system - especially in older people - and obstruct their adaptive immunity. Vaccine skeptics and deniers have weaponized this medical term to deter people from trusting Covid-19 vaccines, which have been proven effective and safe. Vaccine misinformation concerning the coronavirus spike protein has again picked up in recent days.
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